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Decreased cortical octopamine level in basal forebrain lesioned rats: a microdialysis study
G Bendahan1, M L Boatell, N Mahy
1Unit of Biochemistry, School of Medicine, University of Barcelona, Spain.
Neuroscience Letters
|April 2, 1993
Abstract:
Ibotenic acid-induced lesion of the basal forebrain resulted after 13 days in a 90% reduction of octopamine (OA) in the frontoparietal cortex of adult rats, whereas dihydroxyphenylacetic (DOPAC), homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA) acids were not modified as measured by microdialysis and high-performance liquid chromatography (HPLC) with electrochemical detection. At this time, cortical choline acetyltransferase (ChAT) activity was decreased by 34%. The results are discussed with respect to possible octopamine involvement in reduced age-associated performance in neurodegenerative processes.