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[Anaphylactoid reaction to vecuronium]
1Department of Anesthesiology and Intensive Care Medicine, Kanazawa University School of Medicine.
Masui. the Japanese Journal of Anesthesiology
|April 1, 1993
Summary
Vecuronium can cause anaphylactoid reactions, even in patients without allergies. This reaction, triggered by histamine release, highlights the importance of monitoring for adverse events during anesthesia.
Area of Science:
- Anesthesiology
- Clinical Immunology
Background:
- Vecuronium is a neuromuscular blocking agent used in anesthesia.
- The
- priming principle
- aims to reduce the onset time of neuromuscular blockade.
Observation:
- A 4-year-old male experienced bronchospasm and skin rashes after receiving a priming dose of vecuronium.
- Symptoms resolved with aminophylline and steroid treatment.
Findings:
- Immunological studies indicated an anaphylactoid reaction, likely due to physico-chemical histamine release.
- The reaction was not a typical IgE-mediated type I allergic reaction.
- Elevated complement C3 and low plasma IgE were noted.
Implications:
- Vecuronium, despite a low potential for histamine release, can cause adverse reactions.
- Anaphylactoid reactions are possible even in patients with no history of atopy or allergies.
- Vigilance for adverse drug reactions is crucial in perioperative care.