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Human T-lymphotropic virus types I and II

J D Rosenblatt1

  • 1Department of Medicine, University of California, School of Medicine, Los Angeles 90024-1678.

The Western Journal of Medicine
|April 1, 1993
PubMed
Summary

Human T-lymphotropic virus types I and II (HTLV-I and HTLV-II) are oncogenic retroviruses. This review covers their epidemiology, clinical findings in the Americas, and mechanisms potentially causing leukemia and neurologic disease.

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Area of Science:

  • Virology
  • Epidemiology
  • Oncology

Background:

  • Human T-lymphotropic virus types I and II (HTLV-I, HTLV-II) are oncogenic retroviruses.
  • HTLV-I and HTLV-II belong to a family of four known retroviruses, including bovine leukemia virus and simian T-cell leukemia virus.
  • The presence of HTLV-I and HTLV-II in humans has been recognized for over a decade.

Purpose of the Study:

  • To summarize recent epidemiologic and clinical findings of HTLV-I and HTLV-II in the Americas.
  • To discuss the self-regulation mechanisms of HTLV-I and HTLV-II.
  • To explore how these viruses may cause leukemia and neurologic diseases in humans.

Main Methods:

  • Review of recent epidemiologic data.
  • Analysis of clinical findings.
  • Discussion of viral regulatory mechanisms and pathogenesis.

Main Results:

  • Recent epidemiologic and clinical findings regarding HTLV-I and HTLV-II in the Americas are presented.
  • Potential self-regulation pathways for HTLV-I and HTLV-II are discussed.
  • Mechanisms by which HTLV-I and HTLV-II may induce leukemia and neurologic conditions are explored.

Conclusions:

  • HTLV-I and HTLV-II are significant human retroviruses with oncogenic potential.
  • Understanding their epidemiology and pathogenesis is crucial for public health.
  • Further research into viral regulation and disease mechanisms is warranted.

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