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[Hyalinizing trabecular adenoma of the thyroid]
1First Department of Surgery, Yokohama City University, School of Medicine, Japan.
Nihon Geka Gakkai Zasshi
|April 1, 1993
Summary
This case report details a rare hyalinizing trabecular adenoma of the thyroid. Histopathology revealed characteristic cellular and nuclear features, aiding in diagnosis of this uncommon thyroid neoplasm.
Area of Science:
- Endocrinology
- Surgical Pathology
- Cytopathology
Background:
- Hyalinizing trabecular adenoma (HTA) is a rare thyroid neoplasm.
- Accurate histopathological diagnosis is crucial for appropriate patient management.
Observation:
- Puncture-aspiration cytology showed tumor cells with intranuclear inclusions and grooves, arranged around hyaline areas.
- Biopsy revealed spindled to ellipsoidal cells staining for thyroglobulin but not calcitonin.
- Tumor cells exhibited atypical nuclear features and formed funicular structures with central hyaline material.
Findings:
- The hyaline material stained positive for PAS and Laminin, but negative for Congo red.
- Immunohistochemistry confirmed thyroglobulin positivity and calcitonin negativity.
- Distinctive cytological and histological features aid in differentiating HTA from other thyroid lesions.
Implications:
- Understanding the histopathological spectrum of HTA improves diagnostic accuracy.
- This case contributes to the literature on rare thyroid tumors.
- Accurate diagnosis of HTA is essential to avoid misclassification as a malignant neoplasm.