Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Preventive chemotherapy after transurethral prostatectomy: a randomized study]

O Yoshida1, Y Arai, H Takeuchi

  • 1Department of Urology, Faculty of Medicine, Kyoto University.

Hinyokika Kiyo. Acta Urologica Japonica
|May 1, 1993
PubMed
Summary

Preventive chemotherapy using piperacillin (PIPC) followed by tosufloxacin tosilate (TFLX) significantly improved efficacy in transurethral prostatectomy patients. This combination therapy is particularly beneficial for patients with long-term indwelling catheters.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Clinical analysis of urolithiasis in Poh Ai Hospital of I-Lan, Taiwan, R.O.C.--a comparative study with urolithiasis in Japan].

Hinyokika kiyo. Acta urologica Japonica·1992
Same author

[Clinical application of Dornier Lithotripter Compact for upper urinary tract stones].

Hinyokika kiyo. Acta urologica Japonica·1992
Same author

[Japanese clinical statistical data of patients with polyneuropathy].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same author

Immunogenic properties of structurally modified human tissue plasminogen activators in chimpanzees and mice.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1992
Same author

Papillary adenocarcinoma in a seminal vesicle cyst associated with ipsilateral renal agenesis: a case report.

The Journal of urology·1992
Same author

[Hairy cell leukemia successfully treated with deoxycoformycin].

[Rinsho ketsueki] The Japanese journal of clinical hematology·1992

Area of Science:

  • Urology
  • Infectious Diseases
  • Pharmacology

Background:

  • Transurethral prostatectomy (TURP) patients are susceptible to post-operative urinary tract infections (UTIs).
  • Preventive chemotherapy aims to reduce the incidence of UTIs in these patients.
  • Optimizing antibiotic regimens is crucial for improving patient outcomes after TURP.

Purpose of the Study:

  • To evaluate the efficacy of a sequential antibiotic regimen for UTI prevention in transurethral prostatectomy patients.
  • To compare the effectiveness of piperacillin (PIPC) alone versus PIPC followed by tosufloxacin tosilate (TFLX).
  • To assess the influence of indwelling catheter duration on treatment efficacy.

Main Methods:

  • A randomized controlled trial involving 104 transurethral prostatectomy patients with no prior UTIs.

Related Experiment Videos

  • Group A received intravenous PIPC post-surgery. Group B received intravenous PIPC followed by oral TFLX.
  • Efficacy was assessed using physician evaluation and a unified standard including infection onset and bacteriuria levels at ten days post-surgery.

    • Main Results:

    • No significant difference in efficacy was observed between groups when assessed by the primary physician.
    • The unified standard assessment revealed a significantly higher efficacy rate in Group B (88.1%) compared to Group A (62.2%).
    • TFLX administration following PIPC demonstrated increased efficacy, especially in patients with indwelling catheters for four days or longer. No serious adverse events were reported.

    Conclusions:

    • Sequential administration of piperacillin and tosufloxacin tosilate is an effective strategy for preventing UTIs in transurethral prostatectomy patients.
    • This regimen is particularly advantageous for patients requiring prolonged indwelling catheterization.
    • The findings support the use of TFLX as a valuable component in preventive chemotherapy protocols for post-prostatectomy patients.