[Hemodilution therapy for cerebral ischemic acidosis]

The four-vessel (bilateral vertebral arteries and carotid arteries) occlusion rabbit models were used as brain ischemia models. At the beginning of reperfusion, blood was withdrawn and replaced with dextran 20 equivalently until various scale hemodilution was achieved and lasted for 30 min. Hematocrits were 31.7 +/- 1.4%, 23.7 +/- 2.8%, 13.7 +/- 2.5% respectively during hemodilution. Before and after reperfusion for 30, 90 and 180 minutes, internal jugular venous blood samples were taken for gas analysis and lactate acid determination. The results showed that pHv of internal jugular vein was improved in limited and medium hemodilution, and lactate acid level was reduced from 160.17 +/- 26.76 mg/dl to 148.83 +/- 18.98 mg/dl in limited hemodilution group, while it was 184.5 +/- 54.21 mg/dl in the controls after reperfusion for 90 minutes. It is suggested that cerebral ischemia acidosis could be improved by hemodilution, in addition to the clearance of lactate acid. However, the shortage of extreme hemodilution, metabolic acidosis, made it limited for clinical practice.