[Effect of 764-3 on ConA receptors on rat alveolar macrophages]

The changes of concanavalin A (ConA) receptors on alveolar macrophage (AM) surfaces were observed by means of ConA-horseradish peroxidase gold labelling techniques. The results were as follows: 1) The average gold particle number on normal AM surfaces was 1.985 +/- 0.097/microns, distributed uniformly; 2) On AM activated by BLMA6, in vitro, this number had increased to 3.909 +/- 0.314/microns, P < 0.001 compared with the normal group; 3) On AM preincubated with 764-3, the average gold particle number was 1.577 +/- 0.090/microns, significantly lower than that in the BLMA6 group. All results suggest that 764-3 might partially inhibit the expression of ConA-R on AM activated by BL-MA6.