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Urinary bladder carcinoma producing granulocyte colony stimulating factor (G-CSF): a case report with
1Division of Internal Medicine, Nippon Kokan Hospital, Kanagawa, Japan.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1993
Abstract:
A rare case of urinary bladder carcinoma with granulocyte colony stimulating factor (G-CSF) production was reported. In an 83-year-old female, marked neutrophilia in the peripheral blood decreased from 132,500/mm3 to 3,300/mm3 after tumour resection. The tumour was a transitional cell carcinoma. The serum G-CSF level reduced from 238 pg/ml pre-operatively to normal (60 pg/ml) after the operation. Immunohistochemical investigation of the resected tumour with monoclonal antibody specific for G-CSF revealed positive staining in the carcinoma cells, confirming G-CSF secretion.