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Related Experiment Videos

ICI D7288, a novel sinoatrial node modulator

P W Marshall1, W Rouse, I Briggs

  • 1ICI Pharmaceuticals, Bioscience Department II, Macclesfield, Cheshire, England.

Journal of Cardiovascular Pharmacology
|June 1, 1993
PubMed
Summary

ICI D7288, a sinoatrial node modulating agent, effectively reduces heart rate in various animal models. This compound shows potential for treating ischemic heart disease by lowering heart rate without compromising cardiac function.

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Area of Science:

  • Cardiovascular Pharmacology
  • Cardiac Electrophysiology

Background:

  • The sinoatrial (SA) node is the primary determinant of heart rate.
  • Modulating SA node activity is a therapeutic strategy for conditions with elevated heart rate.

Purpose of the Study:

  • To evaluate the cardiovascular effects of the SA node modulating agent, ICI D7288.
  • To assess the potential of ICI D7288 in treating conditions like ischemic heart disease.

Main Methods:

  • In vitro studies using guinea pig isolated atria and SA node.
  • In vivo studies in anesthetized and exercising dogs, and conscious rats.
  • Intracellular recordings from SA node pacemaker cells.

Main Results:

  • ICI D7288 reduced spontaneous beating rate in guinea pig atria and SA node pacemaker cell depolarization rate.

Related Experiment Videos

  • Intravenous administration in dogs dose-dependently reduced heart rate without affecting left ventricular contractility.
  • Oral administration in rats reduced heart rate without impacting blood pressure.
  • Exercise-induced tachycardia in dogs was attenuated, with cardiac output maintained unless heart rate reduction exceeded 30%.

    • Conclusions:

    • ICI D7288 selectively modulates the SA node, reducing heart rate.
    • The compound demonstrates potential therapeutic value for ischemic heart disease by lowering heart rate without adverse effects on cardiac function.