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The pathogenesis of multiple sclerosis. Additional considerations

C M Poser1

  • 1Department of Neurology, Harvard Medical School, Boston, MA.

Journal of the Neurological Sciences
|April 1, 1993
PubMed
Summary
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Multiple sclerosis (MS) is a systemic condition in genetically susceptible individuals, triggered by viral antigens. Alteration of the blood-brain barrier (BBB) is necessary for MS to affect the central nervous system (CNS), potentially involving trauma.

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) Disorders
  • Autoimmune Diseases

Background:

  • Multiple sclerosis (MS) is a systemic condition in genetically susceptible individuals, not initially involving the CNS.
  • It arises from a hyperactive immune response to viral antigens, from infection or vaccination.
  • Progression to CNS involvement requires alteration of the blood-brain barrier (BBB) impermeability.

Purpose of the Study:

  • To explore the mechanisms by which MS affects the CNS.
  • To investigate the role of BBB permeability in MS lesion formation.
  • To examine the potential role of CNS trauma in MS progression.

Main Methods:

  • Review of clinical, neuropathological, and experimental evidence.
  • Analysis of immunological responses and their controversial role in MS.

Related Experiment Videos

  • Examination of factors influencing BBB integrity and CNS lesion development.

    • Main Results:

    • MS develops systemically due to immune response to viral antigens.
    • BBB alteration is crucial for CNS lesions, causing edema and inflammation, with possible demyelination.
    • Mild CNS trauma is identified as a common facilitator of MS lesion development and clinical manifestation.

    Conclusions:

    • The transition of MS to a CNS disease hinges on BBB permeability changes.
    • The precise target of the immune attack in MS (myelin, oligodendrocyte, or BBB) remains debated.
    • CNS trauma is a significant factor in MS progression and symptom onset, alongside viral infections.