[Determination of platelet alpha-granule membrane protein in late pregnancy and oral contraceptive users]

From Oct. 1990 to June 1991, alpha-granule membrane protein (GMP 140) were measured by MoAb radioimmunoassay in normal non-pregnant women (n = 24), normal late pregnancy (n = 26), late pregnancy with pregnancy-induced hypertension (PIH) (n = 27), and oral contraceptive users (n = 23). The results showed that (1) platelet GMP 140 of late pregnant women were significantly higher than that in nonpregnant controls; (2) There was no difference in GMP 140 between late pregnant group and PIH group; (3) Differences were not found among mild, moderate and severe PIH subgroups; (4) Platelet GMP140 was remarkably higher in oral contraceptive users than that in normal controls.