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Molecular cloning of a cDNA encoding a novel small GTP-binding protein
1Section of Bacterial Infection, Hokkaido University, Sapporo, Japan.
FEBS Letters
|August 9, 1993
Abstract:
A cDNA encoding a small GTP-binding protein, S10, was cloned from Jurkat cells. The deduced amino acid sequence of S10 had the structural features characteristic to this family of proteins with highest homology to rab subfamily. Northern blot analysis revealed that this gene is expressed only in lymphoid cell lines and a histiocytic leukemia, U937. Hence, it should have a specialized function in cells derived from the hematopoietic stem cell.