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[Squamous cell carcinoma, basal cell carcinoma]

S Ikeda1, T Suzuki, Y Kiyohara

  • 1Dept. of Dermatology, Saitama Medical School, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 1, 1993
PubMed
Summary

Cisplatin and adriamycin (CA) chemotherapy shows promise for treating squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). This effective neoadjuvant therapy resulted in partial remission in multiple BCC lung metastases.

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Area of Science:

  • Oncology
  • Dermatology
  • Medical Chemotherapy

Context:

  • Squamous cell carcinoma (SCC) treatment in Japan traditionally used peplomycin.
  • Recent advancements include cisplatin-based regimens for SCC, notably cisplatin and adriamycin (CA) chemotherapy.
  • CA chemotherapy demonstrates efficacy in both SCC and basal cell carcinoma (BCC).

Purpose:

  • To evaluate the effectiveness of CA chemotherapy as a neoadjuvant therapy for SCC and BCC.
  • To report outcomes of CA chemotherapy in patients with multiple lung metastases of BCC.

Summary:

  • CA chemotherapy, combining cisplatin and adriamycin, is highlighted as a superior treatment option for SCC compared to peplomycin.
  • The regimen is also effective for basal cell carcinoma (BCC).

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  • In a cohort of patients with multiple lung metastases of BCC treated over six years, CA chemotherapy achieved partial remission (PR) in three instances, with ongoing survival.

    • Impact:

    • CA chemotherapy presents a significant therapeutic advancement for managing SCC and BCC.
    • This neoadjuvant approach offers a promising strategy for advanced BCC with lung metastases.
    • The findings support the broader application of CA chemotherapy in relevant oncological and dermatological settings.