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Updated: Aug 1, 2026

Real-time Live Imaging of T-cell Signaling Complex Formation
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Real-time Live Imaging of T-cell Signaling Complex Formation

Published on: June 23, 2013

Molecules involved in T-cell costimulation

M K Jenkins1, J G Johnson

  • 1Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.

Current Opinion in Immunology
|June 1, 1993
PubMed

Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.

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