Related Experiment Videos
Non-antigen signals for B-cell growth and differentiation to antibody secretion
S Lederman1, M J Yellin, L R Covey
1Columbia University, College of Physicians and Surgeons, New York.
Current Opinion in Immunology
|June 1, 1993
Abstract:
Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.