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A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL gene
S N Jani Sait1, S C Raimondi, A T Look
1Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263.
Genes, Chromosomes & Cancer
|May 1, 1993
Abstract:
Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed-lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene.