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Related Experiment Videos

Cytokine modulation of HIV expression

G Poli1, A S Fauci

  • 1Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Seminars in Immunology
|June 1, 1993
PubMed
Summary

Cytokines, immune system regulators, are implicated in acquired immune deficiency syndrome (AIDS) pathogenesis. Human immunodeficiency virus (HIV) infection influences cytokine production and expression, with activated B cells potentially driving HIV infection progression.

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Area of Science:

  • Immunology
  • Virology
  • Endocrinology

Background:

  • Cytokines are peptide hormones crucial for immune system homeostasis and inflammatory responses.
  • Cytokines play a multifaceted role in the pathogenesis of acquired immune deficiency syndrome (AIDS).

Purpose of the Study:

  • To investigate the role of cytokines in acquired immune deficiency syndrome (AIDS) pathogenesis.
  • To explore the interplay between human immunodeficiency virus (HIV) infection and cytokine production and modulation.

Main Methods:

  • In vitro and in vivo studies examining cytokine production during HIV infection.
  • Analysis of cytokine influence on HIV expression in T lymphocytes and mononuclear phagocytes.

Main Results:

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  • HIV infection induces the production of various cytokines.
  • Cytokines modulate the expression levels of HIV in infected cells.
  • Activated B cells in HIV-infected individuals release HIV-inductive cytokines.

    • Conclusions:

    • Cytokines are significantly involved in the pathogenesis of AIDS.
    • Activated mononuclear cells, especially B cells, contribute to HIV infection progression through cytokine release.