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[The biological activity of human recombinant interleukin-1 beta when administered in vivo]
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|January 1, 1993
Abstract:
Human recombinant IL-1 beta injected intraperitoneally into CBA mice dose-dependently induced leukocytosis, stimulated phagocytosis and reduced tetrazolium nitroblue by peritoneal leukocytes, colony formation by bone marrow cells, enhanced Con A and IL-2-induced proliferation and IL-2 production in thymocytes and splenocytes. Recombinant IL-1 beta restored bone marrow cell proliferation reduced after 5-fluorouracil treatment and significantly increased the survival rates of lethally irradiated mice.