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Malignant osteopetrosis: c-src kinase is not reduced in fibroblasts
G Meyerson1, N Dahl, S Påhlman
1Department of Pathology, University Hospital, Uppsala, Sweden.
Calcified Tissue International
|July 1, 1993
Abstract:
Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could be detected in c-src protein and c-src kinase activity levels between fibroblasts from healthy controls and affected individuals. Thus, impairment of c-src function as an etiological factor in human osteopetrosis appears unlikely in the individuals investigated.