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Cutaneous cylindroma with malignant transformation

A L Gerretsen¹, S C van der Putte, W Deenstra

¹Department of Dermatology, University Hospital Utrecht, The Netherlands.

|September 1, 1993

Summary

Malignant cutaneous cylindroma, a rare cancer, is more aggressive in its multiple tumor form. This aggressive carcinoma shows destructive growth and metastasis, requiring careful histopathologic evaluation.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Malignant cutaneous cylindroma is an exceptionally rare neoplasm.
It presents as either a solitary lesion or part of an autosomal dominant inherited multiple tumor syndrome.

Observation:

Two new cases of malignant cutaneous cylindroma within a single family afflicted with multiple cylindromas are presented.
Clinical and histopathologic data were compared with 26 previously reported cases.

Findings:

Malignant tumors exhibited rapid growth, ulceration, or bleeding, distinguishing them from benign counterparts.
Histopathology revealed a well-differentiated carcinoma in one case and a poorly differentiated tumor with lymph node metastasis in the other.
Metastasis led to patient mortality 2.5 years post-diagnosis.

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Implications:

Malignant cutaneous cylindroma appears more prevalent in the multiple tumor variant.
This aggressive carcinoma demonstrates a propensity for local invasion and distant metastasis.