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Opioid hyperexcitability: the application of alternate opioid therapy
Neil MacDonald1, Linda Der, Sharon Allan
1Alberta Cancer Foundation, University of Alberta, Edmonton, Alb. T6G 2J3 Canada British Columbia Cancer Agency, Victoria, BC V8R IJ8 Canada Queen Elizabeth Hospital, Charlottetown, PEI CIA 8T5 Canada.
Pain
|June 1, 1993
Abstract:
Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.