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Primary structure and functional expression of a cyclic nucleotide-gated channel from rabbit aorta
M Biel1, W Altenhofen, R Hullin
1Institut für Pharmakologie und Toxikologie, Technischen Universität München, Germany.
FEBS Letters
|August 23, 1993
Abstract:
Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been amplified by PCR from cDNA of heart, aorta, sino-atrial node, cerebellum, C-cells and kidney. The complete amino acid sequence of a CNG channel from rabbit aorta has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CNG channel in Xenopus oocytes.