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Published on: January 1, 2016
Quinolones in intracellular infections
1Département de Génétique et Microbiologie, Centre Médical Universitaire, Geneva, Switzerland.
Drugs
|January 1, 1993
Summary
Fluoroquinolones are effective against many intracellular infections due to their favorable pharmacokinetics and in vitro activity. They are valuable in treating infections like typhoid fever and certain mycobacterial diseases.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- Intracellular parasites reside within host cells, posing treatment challenges.
- Fluoroquinolones exhibit favorable intracellular pharmacokinetics, accumulating in phagocytes.
- These properties make them suitable for targeting intracellular pathogens.
Purpose of the Study:
- To review the efficacy of fluoroquinolones in treating various intracellular infections.
- To highlight their pharmacokinetic advantages for intracellular pathogens.
- To assess their role in treating bacterial and mycobacterial infections.
Main Methods:
- Literature review of studies on fluoroquinolone use in intracellular infections.
- Analysis of in vitro activity and clinical outcomes.
- Evaluation of pharmacokinetic data, particularly intracellular accumulation.
Main Results:
- Fluoroquinolones show efficacy against Salmonella spp., tularaemia, and Mediterranean spotted fever.
- They demonstrate significant antimycobacterial activity, useful in combination therapy for tuberculosis and leprosy.
- Monotherapy in brucellosis and chlamydial infections shows limitations.
Conclusions:
- Fluoroquinolones are crucial for treating intracellular infections due to their activity and pharmacokinetics.
- They are effective against a range of pathogens including Salmonella and mycobacteria.
- Careful consideration of specific indications like brucellosis is necessary.
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