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Related Experiment Videos

Fluoroquinolones: interaction profile during enteral absorption

K M Deppermann1, H Lode

  • 1Medical Department, Klinikum Steglitz, Freie Universität Berlin, Germany.

Drugs
|January 1, 1993
PubMed
Summary

Metallic cations like those in antacids and iron supplements significantly reduce fluoroquinolone absorption. This interaction, crucial for severe infection treatment, impacts drug bioavailability and requires careful consideration during co-administration.

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Area of Science:

  • Pharmacology
  • Drug Interactions
  • Infectious Diseases

Background:

  • Fluoroquinolones are vital antibiotics for treating severe bacterial infections globally.
  • Understanding drug interactions is crucial for optimizing fluoroquinolone therapy.
  • This review focuses on absorption-phase interactions of fluoroquinolone antibiotics.

Purpose of the Study:

  • To review drug interactions affecting the absorption of fluoroquinolone antibiotics.
  • To evaluate the impact of common concomitant agents on fluoroquinolone bioavailability.
  • To compare interactions across different quinolone derivatives, including ciprofloxacin and ofloxacin.

Main Methods:

  • Literature review of studies examining fluoroquinolone interactions.
  • Analysis of effects of food, H2-receptor antagonists, anticholinergic drugs, and metallic cations.

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  • Focus on absorption phase bioavailability.

    • Main Results:

    • Food, H2-receptor antagonists, and anticholinergic drugs showed minimal impact on fluoroquinolone bioavailability.
    • Antacids and ferrous sulfate (iron) significantly impaired fluoroquinolone bioavailability.
    • Impaired bioavailability is attributed to chelation forming insoluble complexes with metallic cations.

    Conclusions:

    • Metallic cation-containing compounds, including antacids and iron supplements, markedly reduce fluoroquinolone absorption.
    • The degree of bioavailability impairment varies among different fluoroquinolone agents.
    • Clinicians should be aware of these interactions to ensure effective fluoroquinolone treatment.