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Related Experiment Videos

Fatal overdosage with disopyramide

A M Hayler, D W Holt, G N Volans

    Lancet (London, England)
    |May 6, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Disopyramide overdose commonly causes early unconsciousness and breathing cessation. Despite initial resuscitation, patients rapidly deteriorated with arrhythmias and respiratory failure, leading to pulmonary congestion.

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    Area of Science:

    • Cardiology
    • Toxicology
    • Pulmonology

    Background:

    • Disopyramide is an antiarrhythmic medication.
    • Intentional overdose can lead to severe toxicity.
    • Understanding the clinical course and pathological findings is crucial for management.

    Observation:

    • Five patients presented with deliberate disopyramide overdose.
    • The most frequent initial clinical sign was loss of consciousness following an apnoeic episode.
    • Four patients experienced a temporary response to resuscitation and antiarrhythmic drugs.

    Findings:

    • Patients rapidly deteriorated with cardiac arrhythmias and loss of spontaneous respiration.
    • Necropsy revealed pulmonary congestion in four cases.
    • Pulmonary congestion was consistent with left ventricular failure.

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    Implications:

    • Disopyramide overdose has a high mortality rate.
    • Early and sustained interventions are critical.
    • Left ventricular failure and pulmonary congestion are significant post-mortem findings.