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Updated: Aug 19, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
[Non-A, non-B/C hepatitis]
1Ondokuzmayis Universitesi, Tip Fakültesi Mikrobiyoloji Anabilim Dali.
Abstract:
A recombinant immunoscreening approach was used to clone and identified the genome of the non-A, non-B hepatitis virus. This agent is a positive-stranded RNA virus that appears to be distantly related to the flaviviridae family. A recombinant viral antigen (C100-3) was used to develop a "capture" assay for circulating antibody. Data obtained using this assay indicate that this agent, termed the Hepatitis C virus (HCV), is the major cause of post-transfusion, community-acquired and cryptogenic, NANB. HCV is associated with the development of hepatocellular carcinoma and possibly, other liver diseases. In this article the characteristic of Hepatitis C virus were discussed.
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