Effect of L-type calcium channel modulators on stimulant-induced hyperactivity

The present study investigated the effect of L-type calcium channel modulators on stimulant-induced locomotor activity. The L-channel activator, (+/-)BayK8644, produced a marked, long-lasting enhancement of cocaine-induced activity, while having no effect on amphetamine hyperactivity. Nicardipine reduced cocaine hyperactivity but had no effect on the amphetamine response.