Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene structure and expression in colorectal cancer

J M Pipas1, K Pogue-Geile, G G Finley

  • 1Department of Biological Sciences, University of Pittsburgh, PA 15260.

Advances in Experimental Medicine and Biology
|January 1, 1993
PubMed
Summary

Colorectal cancer progression involves distinct histopathological stages. Molecular studies reveal significant gene alterations during this ordered tumorigenesis process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to 'Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE)': Annals of Oncology, Volume 31, Issue 1, 2020, Pages 79-87.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE).

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Neoadjuvant cetuximab, twice-weekly gemcitabine, and intensity-modulated radiotherapy (IMRT) in patients with pancreatic adenocarcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2012
Same author

Prevalence of the Aleutian mink disease virus infection in Nova Scotia, Canada.

Preventive veterinary medicine·2012
Same author

SV40 Large T antigen mutant data base.

Cytotechnology·2012
Same author

Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis.

Oncogene·2011

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Colorectal cancer (CRC) offers a model for studying tumorigenesis.
  • CRC progression follows a histopathologically ordered sequence of stages.
  • Tissue samples from each stage are accessible for molecular analysis.

Purpose of the Study:

  • To investigate the molecular events driving colorectal cancer progression.
  • To understand gene alterations during the transition from benign to malignant lesions.

Main Methods:

  • Analysis of molecular changes across distinct histopathological stages of colorectal cancer.
  • Examination of gene structure, expression, and activity during tumor evolution.

Main Results:

Related Experiment Videos

  • Multiple genetic and expression alterations are identified during colorectal cancer progression.
  • The study confirms the feasibility of analyzing molecular events in sequential tumor stages.

Conclusions:

  • Colorectal cancer progression is characterized by cumulative molecular changes.
  • Understanding these molecular events is crucial for targeted therapies and early detection.