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Updated: Jun 23, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Management of the patient with left ventricular hypertrophy

O de Divitiis1, A Celentano, G De Simone

  • 1Clinical Methodology-Cardioangiology Unit, Second Medical School, Federico II, University of Naples, Italy.

European Heart Journal
|July 1, 1993
PubMed

Insights

Effective drug treatments, including calcium antagonists, ACE inhibitors, and beta-blockers, can reduce left ventricular hypertrophy (LVH) and associated complications. Careful patient monitoring and gradual introduction of antihypertensive therapy are crucial for managing LVH and preventing cardiovascular events.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Pharmacology

Background:

  • Left ventricular hypertrophy (LVH) requires careful risk stratification and management of associated complications.
  • Non-pharmacological treatment for LVH has limited efficacy, except in obese individuals.
  • LVH is linked to impaired cardiac function and increased risk of arrhythmias.

Purpose of the Study:

  • To review the management strategies for left ventricular hypertrophy (LVH).
  • To evaluate the effectiveness of pharmacological interventions in reducing LVH and its sequelae.
  • To emphasize the importance of tailored antihypertensive therapy in patients with LVH.

Main Methods:

  • Review of existing literature on left ventricular hypertrophy management.
  • Analysis of drug treatment efficacy, focusing on calcium antagonists, ACE inhibitors, and beta-blockers.
  • Discussion of risk stratification, patient monitoring, and antihypertensive therapy strategies.

Main Results:

  • Pharmacological treatments, particularly calcium antagonists, ACE inhibitors, and beta-blockers, are effective in reducing LVH.
  • These drugs help control or reverse associated pathophysiological changes like impaired systolic/diastolic function and arrhythmias.
  • No evidence suggests a beneficial effect of these drugs on myocardial ischemia.

Conclusions:

  • LVH regression is a desirable goal but not always achievable; patient selection for regression is not possible.
  • Controlling LVH and its sequelae can prevent sudden death, heart failure progression, and myocardial infarction.
  • Reconsidering antihypertensive strategies based on LVH presence can decrease cardiovascular morbidity and mortality.

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