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The Mycobacterium bovis BCG 64-kDa surface protein is antigenically shared with different mouse tumor cells and has
The Mycobacterium bovis BCG 64-kDa surface protein, which was found to share antigenic determinants with line 10 hepatoma cells and showed anti-line 10 tumor activity in immunized guinea pigs, has also been found to share common antigenic determinants with Meth A, CT-26 and RL female 1 mouse tumor cells. The 64-kDa protein also demonstrated anti-tumor activity in immunized mice and 37% of the animals challenged with Meth A tumor cells and 50% of those challenged with CT-26 tumor cells completely rejected further tumor growth in the immunized mice. All these data clearly suggest that BCG 64 kDa protein is probably identical with the tumor specific antigen.
The Mycobacterium bovis BCG 64-kDa surface protein, which was found to share antigenic determinants with line 10 hepatoma cells and showed anti-line 10 tumor activity in immunized guinea pigs, has also been found to share common antigenic determinants with Meth A, CT-26 and RL female 1 mouse tumor cells. The 64-kDa protein also demonstrated anti-tumor activity in immunized mice and 37% of the animals challenged with Meth A tumor cells and 50% of those challenged with CT-26 tumor cells completely rejected further tumor growth in the immunized mice. All these data clearly suggest that BCG 64 kDa protein is probably identical with the tumor specific antigen.