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Related Experiment Videos

Endogenous opioids and excessive alcohol consumption

C Gianoulakis1

  • 1Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

Journal of Psychiatry & Neuroscience : JPN
|July 1, 1993
PubMed
Summary
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Ethanol consumption influences the brain

Area of Science:

  • Neuroscience
  • Pharmacology
  • Addiction Research

Background:

  • Alcoholism is a significant societal and health issue, characterized by tolerance and physical dependence.
  • Ethanol's psychoactive effects are not mediated by specific receptors but by modulating neuronal and neuroendocrine systems.
  • Evidence suggests alcohol impacts dopaminergic, serotonergic, and opioidergic systems.

Purpose of the Study:

  • To review the effects of ethanol on the endogenous opioid system.
  • To examine the role of endogenous opioids in controlling alcohol consumption.

Main Methods:

  • Review of existing studies on ethanol's interaction with the endogenous opioid system.
  • Analysis of experimental data, including animal studies on ethanol consumption and opioid antagonists/agonists.

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Main Results:

  • Some behavioral and pharmacological effects of ethanol mimic those of opiates.
  • Morphine administration increased ethanol consumption in experimental animals.
  • Naltrexone administration decreased ethanol consumption in experimental animals.

Conclusions:

  • The endogenous opioid system plays a crucial role in mediating some effects of ethanol.
  • Endogenous opioids are important in regulating voluntary alcohol consumption.
  • Further research into this interaction may inform alcoholism treatment strategies.