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[The effect of low and high molecular weight dextrans on selected lipid parameters in serum. Part 3]
C Rühlmann1, M Koksch, K Hohdorf
1Abteilung Kardiologie/Angiologie, Universität Leipzig.
Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|August 1, 1993
Abstract:
After a ten-day treatment of 21 patients with low molecular weight dextran (MW = 40,000), a decrease in the plasma concentrations of total cholesterol of 25%, LDL-cholesterol of 32% and apoprotein B of 22% was observed. The HDL fraction only showed a reduction of 10%. These dextran effects were dose-dependent. During the post-treatment period of 20 days a continuous increase in the lipid parameters to the preinfusion values was demonstrated. Dextran caused stronger lipid changes in HLP patients than in normolipaemics.