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A monoclonal antibody to alcohol dehydrogenase cross-reacts with human complement component C3
N A Leone1, D B Whitehouse, D M Swallow
1International Institute of Genetics and Biophysics, CNR, Naples, Italy.
Experimental and Clinical Immunogenetics
|January 1, 1993
Abstract:
A monoclonal antibody (mHADH1) against alcohol dehydrogenase was found to cross-react with an abundant protein in human serum. This cross-reacting material was identified unambiguously as the third component of complement (C3), probably part of the alpha-chain, by immunoblotting and immunoprecipitation experiments. The known ADH epitope, HVLPF, recognized by the monoclonal antibody is not, however, present in the C3 sequence.