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Related Experiment Videos

Memory facilitation educed by food intake

Y Oomura1, K Sasaki, A J Li

  • 1Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., Ltd., Hyogo, Japan.

Physiology & Behavior
|September 1, 1993
PubMed
Summary

Food intake boosts brain acidic fibroblast growth factor (aFGF), enhancing memory. This study reveals aFGF

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Physiology

Background:

  • Food intake influences physiological states beyond homeostasis.
  • Brain-gut signaling plays a role in cognitive functions.
  • Acidic fibroblast growth factor (aFGF) is implicated in neural processes.

Purpose of the Study:

  • To investigate the role of acidic fibroblast growth factor (aFGF) in memory facilitation following food intake.
  • To explore the relationship between glucose levels, aFGF, and cognitive performance.
  • To elucidate the neural pathways involved in food-induced memory enhancement.

Main Methods:

  • Measurements of aFGF levels in rat cerebrospinal fluid (CSF) after glucose administration.
  • Intracerebroventricular (ICV) administration of aFGF and anti-aFGF antibodies in rats.
  • Behavioral testing in mice using passive avoidance and Morris water maze tasks after glucose injection.
  • Assessment of memory retention and facilitation under various experimental conditions.

Main Results:

  • CSF aFGF levels increased significantly post-glucose intake or infusion.
  • ICV aFGF administration dose-dependently affected food intake and enhanced memory retention.
  • Glucose-induced memory facilitation in affective and spatial tasks was blocked by anti-aFGF antibodies.
  • Centrally released aFGF in the hippocampus was linked to memory facilitation post-food intake.

Conclusions:

  • Food intake primes the brain for memory facilitation through the release of aFGF.
  • aFGF acts as a key mediator in the cognitive benefits associated with nutrient availability.
  • The findings highlight a novel role for aFGF in preparing the brain for optimal memory function.

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