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Recombinant hepatitis B surface antigen as a carrier of human immunodeficiency virus epitopes
M L Michel1, M Mancini, K Schlienger
1Unité de Recombinaison et Expression génétique, INSERM-U.163, Institut Pasteur, Paris.
Abstract:
Eukaryotic cells transformed with a plasmid expression vector are able to synthesize and assemble HBsAg, a complex multimeric lipoprotein particle. Hybrid particles carrying HIV1 antigenic determinants were constructed and injected into monkeys. A complete immune response including neutralizing antibodies, proliferative and cytotoxic T-cell activities was obtained. Thus, such HIV/HBsAg hybrid particles could be a new approach to multivalent vaccination.
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