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Insulin-like growth factor-I and binding protein-1 can modulate fetal brain cell growth during maternal starvation

G Shambaugh¹, R Glick, J Radosevich

¹Medical Research Service, VA Lakeside Medical Center, Chicago, Illinois.

Annals of the New York Academy of Sciences

|August 27, 1993

Abstract:

1. Stimulation of brain cell growth by fetal plasma is reduced when levels of IGF-I are low and IGFBP-1 are high. 2. Fetal brain cells respond to IGFs in cell culture, and effects of plasma are reduced by addition of IGFBP-1. 3. Increased levels of IGFBP-1 and reduced availability of IGF-I may contribute to reduced brain growth when maternal nutrition is impaired.

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