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Immunoreactive substance P in human saliva. A possible marker of chronic pain
W C Parris1, B V Sastry, J R Kambam
1Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2125.
Annals of the New York Academy of Sciences
|September 20, 1993
Abstract:
In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive objective method of determining SP in saliva may become useful in the evaluation and treatment of chronic pain.