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Near-haploid karyotype in a squamous cell lung carcinoma
V Drouin1, F Viguié, B Debesse
1Laboratoire de Biologie de la Fertilité et de Cytogénétique, Hôtel-Dieu, Hôpital Laennec, Paris, France.
Genes, Chromosomes & Cancer
|August 1, 1993
Abstract:
Cytogenetic analysis of a squamous cell lung carcinoma revealed a near-haploid karyotype with 27 chromosomes, in both primary cultures and an established cell line. The only chromosomes with two homologs present were chromosomes X, 5, 7, and 22. The two X chromosomes were early and late replicating, respectively. No structural rearrangements could be detected. In vitro, the clone evolved by duplication towards hyperdiploidy with 54 chromosomes.