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Cell surface lectins in the immune system

S D Rosen1

  • 1Department of Anatomy, University of California, San Francisco 94143-0452.

Seminars in Immunology
|August 1, 1993
PubMed
Summary
This summary is machine-generated.

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The immune system uses carbohydrates for cell recognition, particularly through selectins (L-, E-, and P-selectin) on immune cells. These receptors bind to specific carbohydrate ligands, mediating crucial cell adhesion processes.

Area of Science:

  • Immunology
  • Glycobiology
  • Cell Biology

Background:

  • The immune system utilizes carbohydrates as key recognition molecules for cellular interactions.
  • Selectins, a family of C-type lectin receptors (L-, E-, and P-selectin), are critical mediators of leukocyte-endothelial cell interactions.

Purpose of the Study:

  • To review current research on selectins and their carbohydrate ligands.
  • To briefly discuss other leukocyte receptors with demonstrated or inferred lectin activity.

Main Methods:

  • Literature review of selectin-carbohydrate interactions.
  • Analysis of C-type lectin domain function in cell adhesion.

Main Results:

  • Selectins mediate cell adhesion by recognizing specific carbohydrate ligands.

Related Experiment Videos

  • These interactions are fundamental to various leukocyte-endothelial cell adhesion processes.

    • Conclusions:

    • Carbohydrate recognition by selectins is a well-established mechanism in cellular immunity.
    • Understanding these interactions is vital for comprehending immune cell trafficking and function.