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Updated: Aug 14, 2026

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes
Published on: August 20, 2015
Complete sequence of a hair-like intermediate filament type II keratin gene
B C Powell1, L A Crocker, G E Rogers
1Department of Biochemistry, University of Adelaide, South Australia.
Abstract:
The Intermediate Filament (IF) superfamily comprises several multigene families, of which the two keratin families are the largest. The keratin IF genes are expressed in epithelial tissues in differentiation-specific patterns and recently we reported the sequence and expression of a hair IF type II keratin gene (KRT2.9). Two related genes were present in the cosmid containing KRT2.9 and we have now sequenced one of them and found that it encodes a hair-like IF type II protein (KRT2.13). However, KRT2.13 is not expressed in the hair follicle. Interestingly there is significant sequence homology between introns 1, 5 and 6 of KRT2.13 and KRT2.9 to suggest gene conversion of these regions or possibly conservation of functional sequences.
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