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Assignment of human beta-galactosidase-A gene to 3p21.33 by fluorescence in situ hybridization
1Department of Hygiene, Teikyo University School of Medicine, Tokyo, Japan.
Human Genetics
|October 1, 1993
Abstract:
GM1 gangliosidosis and Morquio syndrome type B (MPS IVB) are inherited lyosomal storage disorders associated with deficiency of beta-galactosidase-A (beta GALA) activity. A recombinant plasmid containing a biotinylated cDNA (2.4-kb insert) encoding human beta GALA was used to localize the enzyme locus by fluorescence in situ hybridization (FISH). The human beta GALA gene was assigned to 3p21.33 by FISH.