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New developments in microscale separations and mass spectrometry for biomonitoring: capillary electrophoresis and
R D Smith1, J H Wahl, K J Light-Wahl
1Chemical Sciences Department, Pacific Northwest Laboratory, Richland, Washington.
Abstract:
In this article, we briefly highlight the use of capillary electrophoresis for sampling, manipulating, and separating extremely small sample sizes. The extraordinary sensitivity that can be obtained by combined capillary electrophoresis-mass spectrometry is then demonstrated using recent results. We briefly describe the ability to detect noncovalently associated complexes (e.g., double-stranded DNA) by electrospray ionization-mass spectrometry, and conclude with recent results that show the potential for using high-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry for characterization of biomolecules.