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Increased ICAM-1 expression in aortic disease

C A Davis1, W H Pearce, G K Haines

  • 1Department of Surgery, Northwestern University Medical School, Chicago, IL 60611.

Journal of Vascular Surgery
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

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Intercellular adhesion molecule-1 (ICAM-1) is upregulated in diseased aortas, including abdominal aortic aneurysms (AAA) and aortic occlusive disease (AOD). This suggests ICAM-1 plays a role in the development of these degenerative aortic conditions.

Area of Science:

  • Vascular biology
  • Immunohistochemistry
  • Aortic disease research

Background:

  • Vascular adhesion molecules are crucial in inflammatory processes.
  • Intercellular adhesion molecule-1 (ICAM-1), E-selectin, and vascular cell adhesion molecule-1 (VCAM-1) are key players in endothelial cell adhesion.
  • Their role in degenerative aortic diseases like abdominal aortic aneurysms (AAA) and aortic occlusive disease (AOD) requires further investigation.

Purpose of the Study:

  • To evaluate the expression levels of ICAM-1, E-selectin, and VCAM-1 in normal aorta and in aortas affected by AAA and AOD.
  • To determine if there is a differential expression of these adhesion molecules between normal and diseased aortic tissues.

Main Methods:

  • Aortic tissue samples were collected from patients undergoing surgery for AAA (inflammatory and noninflammatory), AOD, and from healthy cadavers (NL).

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  • Immunohistochemistry using avidin-biotin complex method with specific primary antibodies (anti-ICAM-1-AA6, anti-E-selectin-BB11, anti-VCAM-1-4B9) was performed.
  • Tissue slides were scored for inflammation and the percentage of positive cell staining was quantified.

    • Main Results:

    • A trend towards higher inflammatory scores was observed in AAA compared to AOD and NL, though not statistically significant.
    • A significant elevation in ICAM-1 expression was found in the adventitial endothelial cells of both AAA and AOD tissues compared to normal aorta (p < 0.06).
    • E-selectin and VCAM-1 were expressed in all groups, but no statistically significant differences were observed between them.

    Conclusions:

    • The significant upregulation of ICAM-1 in patients with AAA and AOD suggests its involvement in the pathogenesis of these degenerative aortic diseases.
    • ICAM-1 may play a critical role in the initiation or progression of abdominal aortic aneurysms and aortic occlusive disease.
    • Further research into the specific mechanisms of ICAM-1 action in aortic disease is warranted.