Effects of different forms of aprotinin during cardiopulmonary bypass

Effects of two different forms of aprotinin on postoperative blood loss and need for blood replacement were compared in patients undergoing cardiac surgery. One group (n = 46) received 2.10(6) KIA aprotinin (Trasylol), the other group (n = 46) received 2.10(6) PIU aprotinin (Iniprol). Blood loss during the first 12 hours postoperatively was similar (704 +/- 59 ml and 701 +/- 93 ml respectively). Amount of postoperatively transfused blood, fresh frozen plasma, platelets, plasma expanders and fluids was comparable in both groups. Effects of cardiopulmonary bypass on aPTT, PTT, fibrinogen and platelet count were also similar.