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Direct identification of lung cancer cells producing granulocyte colony stimulating factor with monoclonal anti-G-CSF
A Nagatomo1, H Ooike, A Harada
1Department of Internal Medicine, Kawasaki Municipal Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|June 1, 1993
Abstract:
This is a case report of an 82-year-old man with squamous cell lung cancer which produced G-CSF. The leukocyte cell count was elevated to 94,400/mm3. The serum G-CSF concentration was also elevated to 351 pg/ml. This is the first report to demonstrate, by application of immunohistochemical staining techniques directly to tumor tissue obtained at autopsy, squamous carcinoma cells which produce G-CSF. The tumor cells were stained with monoclonal anti-G-CSF antibodies.