Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Heart01:07

Overview of the Heart

14.0K
The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
14.0K
Conduction System of the Heart01:19

Conduction System of the Heart

13.5K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.5K
Anatomy of the Heart01:27

Anatomy of the Heart

120.0K
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
120.0K
Anatomy of the Heart01:20

Anatomy of the Heart

3.2K
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
3.2K
Conduction System of the Heart01:20

Conduction System of the Heart

3.9K
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
3.9K
Tissue Transplantation01:24

Tissue Transplantation

1.0K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurement of the Branching Fraction Ratios R(D^{+}) and R(D^{*+}) Using Muonic Ï„ Decays.

Physical review letters·2025
Same author

Observation of Exotic J/ψϕ Resonant Structure in Diffractive Processes in Proton-Proton Collisions.

Physical review letters·2025
Same author

Observation of New Charmonium or Charmoniumlike States in B^{+}→D^{*±}D^{∓}K^{+} Decays.

Physical review letters·2024
Same author

Search for Time-Dependent CP Violation in D^{0}→π^{+}π^{-}π^{0} Decays.

Physical review letters·2024
Same author

Modification of χ_{c1}(3872) and ψ(2S) Production in pPb Collisions at sqrt[s_{NN}]=8.16  TeV.

Physical review letters·2024
Same author

Amplitude Analysis of the B^{0}→K^{*0}μ^{+}μ^{-} Decay.

Physical review letters·2024

Related Experiment Video

Updated: Feb 6, 2026

Optimization of the Cuff Technique for Murine Heart Transplantation
14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

10.1K

Immunosuppression for heart transplantation

D J White1

  • 1Department of Surgery, University of Cambridge, England, UK.

British Journal of Biomedical Science
|September 1, 1993
PubMed
Summary

Heart transplantation is a major medical achievement. This review covers the history and current use of immunosuppressive drugs, including monoclonal antibodies and FK 506, essential for transplant success.

Area of Science:

  • Cardiology
  • Immunology
  • Transplantation Medicine

Background:

  • Clinical orthotopic heart transplantation represents a significant medical advancement.
  • Immunosuppressive protocols are critical for the success of heart transplantation.

Purpose of the Study:

  • To review the historical development of immunosuppressive protocols in heart transplantation.
  • To detail current immunosuppressive regimens, including their pros and cons.
  • To highlight specific agents like monoclonal antibodies and FK 506.

Main Methods:

  • Literature review of historical and current immunosuppressive strategies.
  • Analysis of advantages and disadvantages of different immunosuppressive approaches.
  • Focus on key immunosuppressive agents used in heart transplant centers.

More Related Videos

A Modified Method for Heterotopic Mouse Heart Transplantion
11:29

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 23, 2014

13.2K
Heterotopic Heart Transplantation in Mice
23:43

Heterotopic Heart Transplantation in Mice

Published on: July 18, 2007

30.3K

Related Experiment Videos

Last Updated: Feb 6, 2026

Optimization of the Cuff Technique for Murine Heart Transplantation
14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

10.1K
A Modified Method for Heterotopic Mouse Heart Transplantion
11:29

A Modified Method for Heterotopic Mouse Heart Transplantion

Published on: June 23, 2014

13.2K
Heterotopic Heart Transplantation in Mice
23:43

Heterotopic Heart Transplantation in Mice

Published on: July 18, 2007

30.3K

Main Results:

  • The evolution of immunosuppression has been key to the success of heart transplantation.
  • Current regimens involve various agents with distinct benefits and drawbacks.
  • Monoclonal antibodies and FK 506 are important in modern immunosuppression.

Conclusions:

  • Immunosuppressive therapy is fundamental to the success of heart transplantation.
  • Understanding the nuances of different immunosuppressive protocols is vital for optimizing patient outcomes.
  • Emerging agents like FK 506 continue to shape the field.