[The effect of 764-3 on alveolar macrophage morphologic changes induced by BLM-A6]

The morphologic changes of alveolar macrophages (AM) were observed by electron microscopy, computer controlled image analysis and stereoscopy. The results showed that 764-3 had no effect on normal AM morphology and structure, but inhibited the BLM-A6 induced increase of volume, specific surface, and lysosome volume density of AM. At the same time, the spreading ability of AM on the slide was markedly reduced by 764-3, indicating that 764-3 can partially prevent the AM activation caused by BLM-A6 in vitro.