Related Experiment Videos
Inhibition of hepatitis B virus in tissue culture by alpha interferon
1Division of Virology, Burroughs Wellcome Co., Research Triangle Park, North Carolina.
Antimicrobial Agents and Chemotherapy
|December 1, 1994
Abstract:
Alpha-n1 interferon (Wellferon), alpha-2a interferon (Roferon), and alpha-2b interferon (Intron-A) inhibited accumulation of intracellular replicative forms of hepatitis B virus (HBV) in chronic producer cells by inhibiting accumulation of RNase-resistant HBV RNA. In contrast, the nucleoside analog FTC (cis-5-fluoro-1- [2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine) inhibited the accumulation of HBV DNA.