Tricuspid valve closure in pulmonary atresia and important RV-to-coronary artery connections

J D Waldman1, R B Karp, J J Lamberti

  • 1Section of Pediatric Cardiology, University of Chicago, Illinois.

Insights

Surgical closure of the tricuspid valve can improve survival for children with pulmonary atresia, intact ventricular septum, and right ventricle-to-coronary artery connections. Early intervention is recommended to prevent myocardial ischemia.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Cardiac Surgery

Background:

  • Children with pulmonary atresia, intact ventricular septum, and right ventricle-to-coronary artery connections face high mortality.
  • Myocardial ischemia occurs due to abnormal blood flow in systole and diastole, compromising heart function.

Purpose of the Study:

  • To evaluate the efficacy of tricuspid valve closure in managing this complex congenital heart defect.
  • To assess the impact of tricuspid valve closure on survival and myocardial ischemia.

Main Methods:

  • Tricuspid valve closure was performed in 10 children, with a balloon trial in 5.
  • Surgical closure of the tricuspid valve was combined with concurrent procedures.
  • Patients were monitored for survival, heart block, and electrocardiogram changes.

Main Results:

  • Seven out of 10 children survived surgical tricuspid valve closure without heart block.
  • Preoperative ischemic changes on ECGs were abolished post-operatively in 4 patients.
  • Two of three non-survivors likely had inoperable conditions due to preoperative ischemia.

Conclusions:

  • Surgical tricuspid valve closure is a viable option for children with pulmonary atresia, intact ventricular septum, and RV-coronary artery connections.
  • Early surgical intervention within the first year of life is recommended.
  • These patients should be managed similarly to those with tricuspid atresia post-operatively.

Related Concept Videos

Chambers of the Heart01:16

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...