Related Experiment Video
Updated: Aug 13, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Tricuspid valve closure in pulmonary atresia and important RV-to-coronary artery connections
J D Waldman1, R B Karp, J J Lamberti
1Section of Pediatric Cardiology, University of Chicago, Illinois.
Insights
Surgical closure of the tricuspid valve can improve survival for children with pulmonary atresia, intact ventricular septum, and right ventricle-to-coronary artery connections. Early intervention is recommended to prevent myocardial ischemia.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
- Cardiac Surgery
Background:
- Children with pulmonary atresia, intact ventricular septum, and right ventricle-to-coronary artery connections face high mortality.
- Myocardial ischemia occurs due to abnormal blood flow in systole and diastole, compromising heart function.
Purpose of the Study:
- To evaluate the efficacy of tricuspid valve closure in managing this complex congenital heart defect.
- To assess the impact of tricuspid valve closure on survival and myocardial ischemia.
Main Methods:
- Tricuspid valve closure was performed in 10 children, with a balloon trial in 5.
- Surgical closure of the tricuspid valve was combined with concurrent procedures.
- Patients were monitored for survival, heart block, and electrocardiogram changes.
Main Results:
- Seven out of 10 children survived surgical tricuspid valve closure without heart block.
- Preoperative ischemic changes on ECGs were abolished post-operatively in 4 patients.
- Two of three non-survivors likely had inoperable conditions due to preoperative ischemia.
Conclusions:
- Surgical tricuspid valve closure is a viable option for children with pulmonary atresia, intact ventricular septum, and RV-coronary artery connections.
- Early surgical intervention within the first year of life is recommended.
- These patients should be managed similarly to those with tricuspid atresia post-operatively.
Abstract:
Mortality is high for children with pulmonary atresia, intact ventricular septum, and important connections between the right ventricle and the coronary arteries because of myocardial ischemia: in systole, suprasystemic right ventricular pressure delivers deoxygenated blood to the coronary artery (or arteries) and in diastole, the right ventricle provides a lower resistance alternative to coronary perfusion of the myocardium. Tricuspid valve closure was performed in 10 such children. None had stenosis of native coronary arteries. A trial of tricuspid valve closure (by balloon) was performed in the cardiac catheterization laboratory in 5 of 10 patients. Seven of 10 children survived surgical closure of the tricuspid valve plus concurrent procedures; none had heart block. Two of the 3 nonsurvivors were probably in inoperable condition due to preoperative myocardial ischemia. Before operation, 4 patients had ischemic changes on electrocardiograms; these changes were abolished after operation. Three of 10 patients have had a Fontan operation with 2 survivors. We conclude that children with pulmonary atresia, intact ventricular septum, important connections between the right ventricle and the coronary arteries, and normal native coronary arteries should have surgical closure of the tricuspid valve within the first year of life and treated thereafter as patients with "tricuspid atresia."
Related Concept Videos
Chambers of the Heart
Deoxygenated blood from the body is received in the right...
Heart Valves
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Coronary Circulation
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Development of the Heart
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Mitral Stenosis I: Introduction
Aortic Regurgitation I: Introduction

