[Effect of doxorubicin on the morphofunctional status of tissue basophils]

It was shown that doxorubicin influenced the morphofunctional state of the peritoneal, mesenteric and dermal tissue basophils which was evident from changes in the total number of the mast cells and the level of their maturity, activity and ability to respond to con A and the antigen. In the late periods after the completion of the treatment with the cytostatic the quantitative changes were slightly pronounced and the functional activity remained high for 3 months. Predisposition to allergic reactions was confirmed by positive intracutaneous tests with horse serum albumin.